Safety and effectiveness of microwave ablation (MWA) as a new thermal ablation technique for lung malignancies (SAMANTHA)

Safety and effectiveness of microwave ablation (MWA) as a new thermal ablation technique for lung malignancies (SAMANTHA) - SAMANTHA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00007163

Enrollment

Registered

2016-05-19

Start date

2015-02-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C78.0 C34

Interventions

Group 1: 1. Screening and Treatment: History, ECOG evaluation (to assess how the disease your need for life skills affected), a pregnancy test in patients of childbearing age, circulatory parameters,

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Primary lung cancer (NSCLC) o Functional irresectable •FEV1 18 years - Tumor size between 5mm and 50mm - Positive proof of vitality: oFDG-uptake in FDG-PET-CT (positive biopsy needed in case of doubts in a positive PET finding in interdisciplinary consensus) and/or osize increase of target lesion in CT and/or opositive biopsy of the target lesion - Distance between target lesion and heart > 20mm

Exclusion criteria

Exclusion criteria: - Life expectancy 45) - Myocardial infarction or stroke within 2 month before intervention

Design outcomes

Primary

Measure	Time frame
The primary endpoint of the study is the safety of microwave ablation (MWA) of lung malignancies up to 5cm size.	—

Secondary

Measure	Time frame
local control after MWA after 4 months (PET-CT) and 13 months (CT) local control after MWA of lung tumors in direct contact with vessels, measuring 3mm or larger characteristics of CT imaging and PET-CT follow-up after MWA local tumor control in association to COPD	—

Countries

Germany

Contacts

Public ContactChristel Besseler

Klinik für Radiologie und Nuklearmedizin

christel.besseler@ed.ovgu.de+49-391-6713071

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026