Impact of antiplatelet effect of monotherapy with clopidogrel on clinical events in patients on vitamin K-antatonists undergoing coronary stent implantation

Impact of antiplatelet effect of monotherapy with clopidogrel on clinical events in patients on vitamin K-antatonists undergoing coronary stent implantation - ExcelsiorOAC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00007144

Enrollment

100

Registered

2014-11-10

Start date

2013-08-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25

Interventions

Group 1: This study enrolls patient undergoing elective coronary stent implantation that have also an indication for oral anticoagulation and are treated with phenprocoumon and clopidogrel (without AS

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - patients undergoing coronary stent implantation with indication for oral anticoagulation for at least 6 months - pretreatment with ASA and clopidogrel - planned treatment with clopidogrel and vitamin K-antagonist following percutaneous coronary intervention - age >=18 years - written informed consent

Exclusion criteria

Exclusion criteria: - high-risk acute coronary syndrome (because usually treated with triple therapy) - fibrinolysis or GP IIb/IIIa antagonist with 5 days before enrollment - contraindication for clopidogrel or vitamin K-antagonist -thrombopenia - known severe coagulopathy - severe disease leading to a life expectancy of less than 1 year

Design outcomes

Primary

Measure	Time frame
death or non-fatal myocardial infarction within 6 months following coronary stent implantation	—

Secondary

Measure	Time frame
prevalence of high on-treatment platelet reactivity further ischemic endpoints such as urgent revascularization	—

Countries

Germany

Contacts

Public ContactWillibald Hochholzer

Universitäts-Herzzentrum Freiburg Bad KrozingenKlinik für Kardiologie und Angiologie II

willibald.hochholzer@universitaets-herzzentrum.de+49 7633 402-4285

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026