The detection of intravitreal opsin concentrations in human eyes suffering from different alterations of the vitreomacular interface.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00007106

Enrollment

350

Registered

2014-10-31

Start date

2015-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H35.3 H33.0 H43.3

Interventions

Group 1: retinal diseases inclusing: epiretinal membrane macular hole retinal detachment diabetic macular edema wet age-related macular degeneration retinal vein occlusion. Patients enrolled into this

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: H35.3 Degeneration of the macula and posterior pole H33.0 rhegmatogenous retinal detachment H43.3 vitreous floater patients are included who will receive a pars plana vitrectomy routinely with following diseases: epiretinal membrane, macular hole, retinal detachment, diabetic macular edema, wet age-related macular degeneration, retinal vein occlusion

Exclusion criteria

Exclusion criteria: vitrectomized eyes former intravitreal anti-VEGF or steroid injections former focal or panretinal laser coagulation former retinal kryocoagulation former uveitis former buckle surgery

Design outcomes

Primary

Measure	Time frame
Intravitreal opsin concentrations in different alterations of the vitreomacular Interface as measured with cytometric bead assay (CBA). Analysis will be performed within 6 months after sampling vitreous specimen. Comparison of intravitreal opsin concentrations among the different retinal diseases and between the retinal diseases and the controll Group (vitreous floater without any acommpanying retinal disease).	—

Measure

Time frame

Intravitreal opsin concentrations in different alterations of the vitreomacular Interface as measured with cytometric bead assay (CBA). Analysis will be performed within 6 months after sampling vitreous specimen. Comparison of intravitreal opsin concentrations among the different retinal diseases and between the retinal diseases and the controll Group (vitreous floater without any acommpanying retinal disease).

—

Countries

Austria, Germany

Contacts

Public ContactThomas Bertelmann

Philipps-Universität MarburgAugenklinik

thomas.bertelmann@staff.uni-marburg.de06421-5861384

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026