Refractory Celiac Disease
Conditions
Interventions
Group 1: The proposed retrospective study is to analyze the prevalent diagnostic and therapeutic pathway for Refractory Celiac Disease (RCD) in Germany. At the same time, a register for RCD will be es
Sponsors
CED Service GmbH
Eligibility
Sex/Gender
All
Age
1 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria follow the criteria to diagnose RCD: Enteropathy with villous atrophy and crypt hyperplasia (Marsh IIIa/b/c); Clinically refractory to a gluten-free diet (GFD) for >1 year; If the patient's clinical situation requires medical treatment directed to treatment of malabsorption, definition of RCD can be based on diet-refractory states <1 year: - enteral / parenteral nutrition - local or systemic acting steroids - azathioprin - other medical therapy directed towards refractory sprue
Exclusion criteria
Exclusion criteria: Exclusion criteria: low adherence to a GFD; existence of other diseases, that provide an explanation for the clinical symptoms: - Small intestinal Crohn´s disease - Lambliasis - Whipple´s disease - Common variable immunodefiency (CVID) - AIDS-associated enteropathy - eosinophilic enteritis - Autoimmune enteropathy - Radiation-induced enteritis - Intestinal tuberculosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary goal is to implement a Germany-wide Registry for Refractory Celiac Disease (RCD) patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| A questionnaire based observation trial ist o be performed associated with the identification of RCD patients. Physicians, treating RCD patients, will fullfill the questionnaire containing data of the chosen diagnostic and therapeutic RCD strategy. | — |
Countries
Germany
Contacts
Public ContactKaren Schmidt
CED Service GmbHc/o GISG Organisationsbüro
Outcome results
None listed