Identifikation and Evaluation of different gene loci for nsCL/P and nsCPO in a Vietnamese population

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006855

Enrollment

300

Registered

2015-05-15

Start date

2015-11-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q37.0 Q37.1 Q37.2 Q37.3 Q37.4 Q37.5 Q37.8 Q37.9 Q35.1

Interventions

Group 1: Peripheral venous blood samples (5-10ml EDTA blood) or saliva samples (2ml) are obtained from cases for DNA-extraction. DNA extraction and genotyping are performed at the Department of Genom

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients, with nsCL/P or nsCPO Patients, whose four grandparents are of Vietnamese descent. written consent to participate in the study. ASA-group 1-3. Inclusion criteria control patients: Patients, without a syndrome Patients, whose four grandparents are of Vietnamese decent. written consent to participate in the study. ASA-group 1-3.

Exclusion criteria

Exclusion criteria: Exclusion criteria patient: no written consent to participate in the study. patients with a syndrome ASA-group 4-8. Exclusion criteria control: Patients, with a CL/P or CPO or signs of a CL/P or CPO Relatives of a cleft patient no written consent to participate in the study. patients with a syndrome ASA-group 4-8.

Design outcomes

Primary

Measure	Time frame
The primary end point of the study is to verify the identified genetic loci respectively identify further genetic loci or genes causative for non-syndromic cleft lip and palate (nsCLP) or cleft palate only (nsCPO) in a Vietnamese population.	—

Secondary

Measure	Time frame
Evaluation of phenotyp-genotyp correlation	—

Countries

Vietnam

Contacts

Public ContactAlina Hinrichs

Uniklinik Köln

alina.hinrichs@uk-koeln.de00492214784741

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026