Incidence and risk factors of viral infections in patients after liver transplantation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006754

Enrollment

Registered

2014-09-17

Start date

2014-11-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing orthotopic liver transplantation from deceased donors K74.6 C22.0

Interventions

Group 1: 80 patients with liver transplantation will be included. The following parameters will be screened on day 0-1-2-7-14-21-28 after transplantation: Anamnesis (acute/chronic), general infectiolo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Liver transplantation at the center of transplantation in Heidelberg • Written and signed informt consent • Age > 18 years

Exclusion criteria

Exclusion criteria: Non-Compliance to the including criteria’s

Design outcomes

Primary

Measure	Time frame
Incidence and progress of viral infections in patients with liver transplantation. The determination of the initial viral findings and the course by using ELISA- and PCR-methods (Polymerase Chain Reaction) for HSV (herpes simplex virus) and CMV (Cytomegalovirus) detection from blood plasma. The effectiveness of an antiviral prophylaxis to prevent invasive viral infection will also be determined.	—

Secondary

Measure	Time frame
Estimation of the validity of scoring systems (APACHE II, SOFA, MELD) and clinical laboratory parameters for the prognosis of viral infection in liver transplanted patients. Development of a scoring system to estimate the infection risk and to reduce the over-treatment. Evaluation of acetylcholinesterase and butyrilcholinesterase as new marker for synthesis performance of the new donor organ or as preterm infection parameter.	—

Measure

Time frame

Estimation of the validity of scoring systems (APACHE II, SOFA, MELD) and clinical laboratory parameters for the prognosis of viral infection in liver transplanted patients. Development of a scoring system to estimate the infection risk and to reduce the over-treatment. Evaluation of acetylcholinesterase and butyrilcholinesterase as new marker for synthesis performance of the new donor organ or as preterm infection parameter.

—

Countries

Germany

Contacts

Public ContactStefan Hofer

Klinik für Anaesthesiologie Universitätsklinikum Heidelberg

stefan.hofer at med.uni-heidelberg.de+49 (0) 6221-56 377 87

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026