Serial Evolution of Mismatch in Acute Stroke for therapeutic approaches within the first 24 hours

Serial Evolution of Mismatch in Acute Stroke for therapeutic approaches within the first 24 hours - MISMATCH24

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006752

Enrollment

Registered

2015-06-25

Start date

2015-04-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63

Interventions

Group 1: Multiple measurements with Magnetic Resonance Scanner within up to 24 hours after the stroke

serial measurement of the ASL/DWI (arterial spin labeling/diffusion weighted imaging) MRI (magnetic resonance imaging) Mismatch. Study with 3 steps, 25 patients per step.

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. 18-85 years 2. Acute ischemic stroke of the anterior circulation within 4.5 (Step II) or 9 hours (Steps I and III) of symptom onset. 3. Clinically stable state 4. NIHSS =2 5. Signed informed consent of the patient or legal guardian

Exclusion criteria

Exclusion criteria: 1. MRI contraindication 2. pregnancy (betaHCG urin/serum) 3. endovascular or other operative procedures planned within next 24hrs. 4. life expectancy <3months 5. Diagnosed intracerebral bleeding before study inclusion 6. no informed consent obtainable, no legal guardian 7. examination with MR-contrast agent (gadolinium derivate) less than 24hrs before study inclusion.

Design outcomes

Primary

Measure	Time frame
Serial/longitudinal change in ASL/DWI Mismatchvolume. Step I: 5 consecutive MRI scans within 1 hour, as soon as possible after symptom onset. 1 Follow-Up MRI after 24h (+/- 3h). Step II: 1. MRI scan at baseline as soon as possible after symptom onset. MRI scans at 1.5, 3, 4.5, 6, 7.5, 9hrs fter symptom onset. If inclusion after 3hrs, no measurment at 1.5 and 3 hrs. 1 Follow-Up MRI after 24h (+/- 3h). Step III: 1. MRI scan at baseline as soon as possible after symptom onset. MRI scans at 9, 12, 16, 20, 24hrs after symptom onset.	—

Measure

Time frame

Serial/longitudinal change in ASL/DWI Mismatchvolume. Step I: 5 consecutive MRI scans within 1 hour, as soon as possible after symptom onset. 1 Follow-Up MRI after 24h (+/- 3h). Step II: 1. MRI scan at baseline as soon as possible after symptom onset. MRI scans at 1.5, 3, 4.5, 6, 7.5, 9hrs fter symptom onset. If inclusion after 3hrs, no measurment at 1.5 and 3 hrs. 1 Follow-Up MRI after 24h (+/- 3h). Step III: 1. MRI scan at baseline as soon as possible after symptom onset. MRI scans at 9, 12, 16, 20, 24hrs after symptom onset.

—

Secondary

Measure	Time frame
DWI MRI Lesion Volume measured at the above mentioned time points	—

Countries

Germany

Contacts

Public ContactJan Sobesky

Charité Universitätsmedizin BerlinCentrum für Schlaganfallforschung Berlun

jan.sobesky@charite.de030 450 560 010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026