healthy participants
Conditions
Interventions
Group 1: CRH-Injection, 1ml, on 2 days
NaCl-Injection, 1ml, on 2 days
Group 2: NaCl-Injection, 1ml, on 4 days
Sponsors
Klinik für Endokrinologie und Stoffwechselerkrankungen
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: healthy male non-smokers at the age of 18 to 40 years
Exclusion criteria
Exclusion criteria: immunological, endocrine, cardiovascular, hemic or psychiatric diseases, hightened BMI, allergy concerning during the study used substances, liver- oder kidney-disease, chronic obstructive lung disease, dependancy or diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| it will be measured ACTH in plasma, Cortisol in plasma, Cortisol in saliva: before the injection and 15, 30, 45, 60, 120 and 180 minutes after the injection | — |
Secondary
| Measure | Time frame |
|---|---|
| Heartrate and pulse before the injection and 15, 30, 45, 60, 120 and 180 minutes after the injection side effects and psychological parameters via standardized questionnaires about one week before and during the study at the same time points as mentioned above. Following questionnaires were used: SSAS, HADS, BIS/BAS, BMQ, PSQ, Adherence Scale Marburg, STAI-State, STAI-Trait, SWE, SFA-K, GASE-P. Additionally we asked for general frequency of side effects, estimation of probability of side effects and occurrence of specific side effects. We also asked for a estimation of the beverage concerning different dimensions. | — |
Countries
Germany
Contacts
Public ContactAnna Lena Kahl
Institut für Medizinische Psychologie
Outcome results
None listed