brain tumors (benign, malignant, or unclear structural epilepsy G40 D33 C71 D43
Conditions
Interventions
Group 1: - individually-tailored, pre-operative examination using advanced MR methods
- additionally, depending on endangered system, pre- and postoperative language testing, structured clinical exam
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Epileptogenic or tumorous lesion in the central region OR in cortical language regions OR near the optic radiation with given or possible indication for neurosurgery
Exclusion criteria
Exclusion criteria: - metal implants (vascular clips or coils, orthopedic screws, cardiac pacemakers, shunts) unless explicitly and in writing certified to be MRI compatible - orthodontic brackets (removal may be required for clinically-indicated MRI exams, but will not be performed solely for study-related MRI exams) - history of injuries possibly introducing metal into the body (high-speed trauma, shrapnel, metal workers etc.) - pregnancy (a pregnancy test will be required for all girls > 12 years in case of anamnestic doubts)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of preoperatively examining the language domain using advanced MRI methods (in particular, functional MRI) in children with brain tumors or structural epilepsy. Feasibility is defined as the ratio of successfully performed, interpretable exams. | — |
Secondary
| Measure | Time frame |
|---|---|
| Feasibility of preoperatively examining the sensorimotor and the visual system using advanced MRI methods (in particular, diffusions MR tractography) in children with brain tumors or structural epilepsy. Feasibility is defined as the ratio of successfully performed, interpretable exams. | — |
Countries
Germany
Contacts
Public ContactMarko Wilke
Universitäts-Kinderklinik, Abt. III (Neuropädiatrie)Interdisziplinärer Arbeitsbereich Experimentelle Pädiatrische Neurobildgebung
Outcome results
None listed