Spatially-resolved assessment of cerebral autoregulation in patients with acute partial anterior circulation stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006564

Enrollment

Registered

2014-11-06

Start date

2014-11-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63

Interventions

Group 1: In the first study arm patients aged between 18-85 years with unilateral Media infarction within the last 96-144 hrs are included who have given their consent for study participation and anon

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Acute middle cerebral artery stroke 96-144 hours after onset Informed consent in study participation and anonymous scientific use of data

Exclusion criteria

Exclusion criteria: Missing cooperation Peripheral arterial occlusive disease Other acute ischemic stroke within he last 3 months High-grade stenosis of internal carotid artery or middle cerebral artery (>50%)

Design outcomes

Primary

Measure	Time frame
The primary objective is the possibility of measurement of cerebral autoregulation from spontaneous fluctuations in blood pressure at the time of the study (96-144h after infarction). For each patient and experimentee the mean autoregulation parameters (correlation coefficient index (CCI) between mean ABP and NIRS signals, HbTot, hbox and HbRed [MxHbTot, MxHbOx, MxHbRed]) in all 52 channels are calculated. On the basis of these average values ??we determine by means of a Wilcoxon-rank-sum-tests whether a separation of the groups and thus a measurement of the cerebral auto regulation is possible.	—

Measure

Time frame

The primary objective is the possibility of measurement of cerebral autoregulation from spontaneous fluctuations in blood pressure at the time of the study (96-144h after infarction). For each patient and experimentee the mean autoregulation parameters (correlation coefficient index (CCI) between mean ABP and NIRS signals, HbTot, hbox and HbRed [MxHbTot, MxHbOx, MxHbRed]) in all 52 channels are calculated. On the basis of these average values ??we determine by means of a Wilcoxon-rank-sum-tests whether a separation of the groups and thus a measurement of the cerebral auto regulation is possible.

—

Secondary

Measure	Time frame
Secondary objective is the description of a spatial disturbance at the time of investigation (96-144 h after infarction). For each group (patients and control group) an average value of the autoregulation parameters in each of the 52 channels is calculated. Based on these mean values??, then the Wilcoxon-rank-sum-test determines whether there is a deviation between the groups for each channel. In this way we can find out whether the disturbance of autoregulation is only present in a sub-region (i.e. single channel) or in larger areas.	—

Measure

Time frame

Secondary objective is the description of a spatial disturbance at the time of investigation (96-144 h after infarction). For each group (patients and control group) an average value of the autoregulation parameters in each of the 52 channels is calculated. Based on these mean values??, then the Wilcoxon-rank-sum-test determines whether there is a deviation between the groups for each channel. In this way we can find out whether the disturbance of autoregulation is only present in a sub-region (i.e. single channel) or in larger areas.

—

Countries

Germany

Contacts

Public ContactMaximilian Oeinck

Universitätsklinikum FreiburgNeurologie

maximilian.oeinck@uniklinik-freiburg.de0761 270 50010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026