Maternal and fetal serum levels of DKK-1 and the placental expression of ß-Catenin in pre-eclamptic and normal pregnancies as well as the postpartal observation of sFlt-1/PlGF ratio and its correlation with clinical and biochemical courses.

Maternal and fetal serum levels of DKK-1 and the placental expression of ß-Catenin in pre-eclamptic and normal pregnancies as well as the postpartal observation of sFlt-1/PlGF ratio and its correlation with clinical and biochemical courses. - PPP Trial

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006526

Enrollment

Registered

2016-03-01

Start date

2014-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

O14

Interventions

Group 1: Preeclamptic pregnancies are examined prior to birth. Routine clinical examinations are done, in addition to biomarkers (sFlt-1, PLGF, DKK-1, ß-Catenin). The placentae are biopsied, ß-Catenin

Eligibility

Sex/Gender

Female

Age

16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Diagnosis of Preeclampsia. Control: Normal pregnancies.

Exclusion criteria

Exclusion criteria: Below 16 years of age. Maternal underlying chronic diseases. No signing of consent.

Design outcomes

Primary

Measure	Time frame
prepartal and postpartal serum sFlt-1/PlGF ratio course in postpartal patients with pre-eclampsia. serum DKK-1, ß-Catenin Placental Expression in pre-eclamptic pregnancies.	—

Secondary

Measure	Time frame
Difference between mild and severe pre-eclampsia regarding biomarkers (DKK1, ß-Catenin and postpartal markers: sFlt-1/PlGF)	—

Countries

Germany

Contacts

Public ContactAmr Hamza

Universitätsklinikum des Saarlandes

amr.hamza@uks.eu06841-1628145

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026