Effects of Endurance Training under Normobaric, Hypoxic Conditions on Fatigue in Patients with Multiple Sclerosis: Results of a Randomized, Prospective Pilot Study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006307

Enrollment

Registered

2014-07-17

Start date

2008-07-14

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G35

Interventions

Group 1: therapy group: endurance training in normobaric hypoxia. symptom-specific inpatient rehabilitation (period of 14 days) + 12x 45 min endurance training on a bicycle ergometer, six days a week

Eligibility

Sex/Gender

All

Age

18 Years to 110 Years

Inclusion criteria

Inclusion criteria: patients over 18 years of age MS according to the McDonald criteria [19] chronic progressive or relapsing-remitting MS with walking ability (EDSS = 6) and self-reported fatigue Written informed consent

Exclusion criteria

Exclusion criteria: Patients with severe cardiopulmonary disease glucocorticosteroid therapy within the previous 30 days, serious functional limitations (i.e. high spasticity of the legs) limiting the ability to use the cycle ergometer as well as severe cognitive deficits that would have made it impossible to understand directions

Design outcomes

Primary

Measure	Time frame
fatigue: questionnaire: Würzburger Erschöpfungsinventar Multiple Sklerose (WEIMuS). Baseline, 7th and 14th day after baseline.	—

Secondary

Measure	Time frame
Endurance capacity: 6 minute walk test recorded at baseline and 14th day after baseline.	—

Countries

Germany

Contacts

Public ContactPeter Flachenecker

Neurologisches Rehabilitationszentrum Quellenhof Bad Wildbad

peter.flachenecker@sana.de07081 1730

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026