DIMDI: E.88.9 "metabolic syndrome, metabolic disorder, unspecified" E66.0 I10.0 E11
Conditions
Interventions
Group 1: Control group: 37 participants with metabolic syndrome without diabetes mellitus type 2, baseline: blood samples, adipose tissue biopsies,
after 3 months: blood samples
after 6 months: blood
Sponsors
Institut für Klinische Chemie und Pathobiochemie Otto-von-Guericke Universität Magdeburg
Eligibility
Sex/Gender
Male
Age
40 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. metabolic syndrome with abdominal obesity (waist circumference > 102 cm) 2. meet two additional criteria for metabolic syndrome as defined by national Cholesterol Education Program Adult Treatmen Panel III guideliens: - fasting TG conc. > 150 mg/dl - HDL-C 110 mg/dl - high blood pressure >140 mmHg systolic and /or > 90 mmHg diastolic or current treatment by anti-hypertensive medication
Exclusion criteria
Exclusion criteria: 1. Smoking 2. surgical procedure for weight loss within the previous 6 month 3. uncontrolled diabetes (HbA1c > 10%) 4. severe renal dysfunction (creatinin concentration > 2.0 mg/dl) 5. active liver disease 6. obesity of known endocrine origin 7. significant haematology abnormalities 8. not able to walk at least 30 minutes per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of molecular networks, that are involved in lifestyle-induced weight loss and result in improved insulin sensitivity and in a decrease of inflammatory processes. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Identification of novel approaches for therapy of the metabolic syndrome, obesity and diabetes mellitus type 2. 2 Identification of new biomarkers for the metabolic syndrome and associated diseases. | — |
Countries
Germany
Outcome results
None listed