G20
Conditions
Interventions
Group 1: healthy volunteers, age-matched
(EEG recording with a 128-channel-system from the head surface and synchronous measurment of the EMG from the right forearm during the conduction of simple mov
intraoperatively: the above mentioned electrophysiological measurements will be accompanied by the recording of local field potentials as well as single cell activity from the target structures of dee
perioperatively, in addition to EEG and EMG, local field potentials will be recorded by the use of externalized electrodes)
Sponsors
Uniklinik Köln, NeurologieArbeitsgruppe für Bewegungsstörungen und Tiefe Hirnstimulation
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: • Male and female participants between 30 and 80 years of age • Right handed persons • Capability of signing an informed consent Parkinson’s patients: • Male and female patients with the diagnosis of an IPS according to the guidelines of the DGN • Right handed patients • Patients with the indication for receiving deep brain stimulation (target areas: STN, GPi, Vim) with uncontrollable motor symptomes due to strong dyskinesia and/ or ON/OFF fluctuations • positive motor response to L-Dopa or Apomorphine; • Patients between 30 and 80 (in order to exclude genetic variants of the disease); • time period of the symptomes longer than 4 years (differential diagnosis); • patients have to be able to sign an informed consent; • Ability to cooperate during the measurements
Exclusion criteria
Exclusion criteria: Healthy subjects: • non- "sui juris" patients, underaged persons as well as subjects which are judically sent to an institution • diagnosis of an idiopathic parkinson syndrom or any other neurological disease • participants that take drugs regularly which influence the nervous system and which can not be stopped the evening before the experiment • severe internal comorbidities • presence of psychiatric diseases •impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers Parkinson’s patients: • non- "sui juris" patients, underaged persons as well as subjects which are judically sent to an institution • patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia • patients with severe frontal executive disturbances • presence of a Parkinson-Plus-Syndrom like corticobasal degeneration, progressive supranuclear palsy or multisystem atrophy • other hypokinetic movement disorders like MPTP- or manganese intoxication, chorea Huntington, subcortical arteriosclerotic encephalopathy or psychogenic movement disorder • clinically relevant abnormalities in preoperative MR-Images like ischemia, or cerebral athropy • previous surgeries in the ZNS due to, for example, brain tumors, epilepsy or vascular reasons • severe internal comorbidities • presence of psychiatric diseases • impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological, oscillatory coupling between EEG and EMG in the beta range (13-30 Hz) on different measurement days without treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparision of pathological, electrophysiological acitivity for two Parkinsons-Subtypes (tremor-dominant versus akinetic rigid) | — |
Countries
Germany
Contacts
Public ContactElfriede Stubbs
Klinik und Poliklinik für NeurologieArbeitsgruppe Bewegungsstörungen und Tiefe HirnstimulationStudienbüro
Outcome results
None listed