I63
Conditions
Interventions
Group 1: Stroke patients undergo aortic MRI (3D multicontrast MRI and 4D flow MRI) for the detection and evaluation of atherosclerotic plaques and analysis of blood flow.
Group 2: Ophthalmic patients
Sponsors
Universitätsklinikum Freiburg Abteilung Neurologie und Neurophysiologie
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Stroke patients: male and female, >49 years of age, acute stroke, cryptogenic stroke etiology after routine diagnostics (without TEE), visible ischemic lesion on cerebral imaging. 2. Control patients: male and female, >49 years of age, no history of cerebral or retianl ischemia.
Exclusion criteria
Exclusion criteria: Contraindications for MRI (ferromagentic prosthesis, cardiac pacemaker, implantable cardioverter defibrillator, insulin pump, large-scale tattoos with metalliferous pigment, artificial heart valves, pregnancy, chochlea implant, copper-bearing contraceptive coil, non-removable piercings, shell splinters or other metallic material), cardiac arrhythmias, bad general condition, no informed consent obtainable, strong claustrophobia, body weight over 130kg, refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative analysis of the frequency of retrograde embolization from complex plaques of the descending aorta into the supra-aortic arteries in patients with undetermined and determined stroke etiology and controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quantification of plaque morphology using 3D multicontrast MRI. 2. In stroke patients: Testing the hypothesis that plaques occur primarily on locations with critically altered WSS and reduced PWV. 3. Correlation of aortic elasticity and flow reversal in the descending aorta. | — |
Countries
Germany
Contacts
Public ContactThomas Wehrum
Universitätsklinikum FreiburgAbteilung Neurologie und Neurophysiologie
Outcome results
None listed