obesity-associated metabolic diseases
Conditions
Interventions
Group 1: 20 obese women (BMI greater or equal 30 kg/m²) underwent a caloric restriction for 28 days. The dietary intervention includes a formula diet with a daily energy intake of 800kcal with additio
Sponsors
Bundesministerium für Bildung und Forschung Dienstsitz Berlin
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: BMI >= 30kg/m²; Stable weight during the last 3 months (+/-2kg); Non-smokers; Signed informed consent
Exclusion criteria
Exclusion criteria: Severe general diseases, e.g. cancer, COPD, severe heart disease (e.g. pacemaker), progressive renal failure, severe psychiatric or neurological diseases; Diabetes; Continuous treatment with oral anticoagulants or antithrombotics (except ASS 100); Malabsorption syndromes; Autonomous neuropathy; Poor compliance; lactose intolerance, sucrose intolerance, sucralose intolerance; Lack of written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut permeability (using polyethylene glycol and sugar absorption test), changes in colon microbiota, inflammation marker in plasma as well as in peripheral immune cell sub-populations. [Timeframe: baseline, after a 28–day intervention period, 14 days after intervention is terminated] | — |
Secondary
| Measure | Time frame |
|---|---|
| insulin sensitivity, body composition, basal metabolic rate, blood parameters (fasting glucose, fasting insulin, liver function, kidney function, electrolytes, lipid profile, DNA, inflammation marker), blood pressure, pulse, eating behavior. [Timeframe: baseline, after a 28–day intervention period, 14 days after intervention is terminated] | — |
Countries
Germany
Contacts
Public ContactBeate Ott
Else Kröner-Fresenius-Zentrum für ErnährungsmedizinLehrstuhl für ErnährungsmedizinTechnische Universität München
Outcome results
None listed