Simulation of periodontal pathomechanisms in vitro using parts of human teeth

Simulation of periodontal pathomechanisms in vitro using parts of human teeth - PDL-LS-2014

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006177

Enrollment

Registered

2014-06-06

Start date

2014-06-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aggressive periodontitis K05.3

Interventions

Group 1: cell culture of human PDL-cells with different gene knock-outs, stimulation by inflammatory noxa, evaluation of cytokines Group 2: cell culture of human PDL-cells, stimulation by inflammatory

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - at least one tooth with the need for extraction - 18 years or older - Contractually capable - Written informed consent

Exclusion criteria

Exclusion criteria: - persons with relationship of dependence to sponsor or examiner - commitment to an institution by judicial or official order

Design outcomes

Primary

Measure	Time frame
Secretion of proinflammatory cytokines after stimulation by qRT-PCR	—

Secondary

Measure	Time frame
Impact of surface morphology on the morphology of human PDL-cells	—

Countries

Germany

Contacts

Public ContactSonja Derman

Poliklinik für Zahnerhaltung und Parodontologie Zentrum für Zahn-, Mund- und Kieferheilkunde Uniklinik Köln

sonja.derman@uk-koeln.de+49 221 478 7174

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026