Comparison of two surgical methods for the treatment of CIN: Classical LLETZ (Large Loop Excision of the Transformation Zone) versus isolated resection of the colposcopic apparent lesion

Comparison of two surgical methods for the treatment of CIN: Classical LLETZ (Large Loop Excision of the Transformation Zone) versus isolated resection of the colposcopic apparent lesion - ECO-ROCS trial (Evaluation of Clinical Outcome after Reduction of Conization Size)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006169

Enrollment

1000

Registered

2014-07-30

Start date

2014-09-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CIN III N87.2

Interventions

Group 1: LLETZ (Large Loop Excision of the Transformation Zone) Group 2: Resection of the dysplastic lesion with no additional resection of the transformation zone

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: CIN III, positive HPV test

Exclusion criteria

Exclusion criteria: -pregnancy until 6 months postop -malignant diseases requiring treatment -intake of immunosuppressants -HIV

Design outcomes

Primary

Measure	Time frame
Negative HPV test 6 and 12 months after the operation	—

Secondary

Measure	Time frame
resection margin of the cone specimen, pap smear 6 and 12 months postop	—

Countries

Germany

Contacts

Public ContactTheresa Kolben

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe - Großhadern

theresa.kolben@med.uni-muenchen.de089-4400-0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 17, 2026