Effects of implementation of KDIGO guidelines controlled by biomarkers in cardiac surgery on incidence and severity of acute kidney injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006139

Enrollment

276

Registered

2014-07-03

Start date

2014-08-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OPS-2013: 5-361 (bypass surgery) OPS-2013: 5-35 (cardiac valve and septum surgery) N17

Interventions

Group 1: Control group: postoperative treatment: standard of care. - hemodynamic: MAP > 65 mmHg, CVP 8-10 mmHg - no avoidance of ACE inhibitors - no avorestriction of radiocontrast procedures - blood

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Cardiac surgery 2. (TIMP-2) * (IGBP7)-urine concentration>=0,3 3. Informed consent

Exclusion criteria

Exclusion criteria: 1. Patients with pre-existing kidney disease not requiring RRT (GFT < 30mL/min) 2. patients with pre-existing RRT 3. patients with a (glomerulo)nephritis, interstitial nephritis or vasculitis 4. pregnancy 5. patients after kidney transplantation

Design outcomes

Primary

Measure	Time frame
Incidence of acute kidney injury in the first three postoperative days	—

Secondary

Measure	Time frame
- severity of AKI - renal recovery (also GFR and creatinine levels at discharge and after 30, 60 and 90 days) - mortality after 30, 60 and 90 days - ICU and hospital stay - MAKE (major adverse kidney events) after 30, 60 and 90 days - biomarkers at the beginning (randomization) and 12 h postoperative	—

Countries

Germany

Contacts

Public ContactAlexander Zarbock

Universitätsklinikum Münster Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

zarbock@uni-muenster.de02518347255

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026