A randomized controlled, single-blinded pilot study to investigate the effect of lipid emulsions on alveolar leukocyte recruitment in volunteers after endotoxin-inhalation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006131

Enrollment

Registered

2014-05-14

Start date

2001-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy participants J80

Interventions

Group 1: Infusion of 350ml of a 10% fish oil-based lipid emulsion on day 1 and day 2 over a period of 12h each. Inhalation of endotoxin (individuel dose) Group 2: Infusion of 350ml of a 10% soybean oi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: Hyperreactive bronchial system Pregnancy Allergy against study medication

Design outcomes

Primary

Measure	Time frame
Leukocytes in broncho-alveolar lavage 8 or 24 h after inhalation	—

Secondary

Measure	Time frame
Cytokines in broncho-alveolar lavage 8 or 24h after endotoxin inhalation	—

Countries

Germany

Contacts

Public ContactKonstantin Mayer

Medizinische Klinik II, Universitätsklinikum Gießen und Marburg

Konstantin.Mayer@uglc.de004964198556743

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 4, 2026