Regulation of prefrontal brain activity with fMRI neurofeedback in healthy subjects and patients with posttraumatic stress disorder

Regulation of prefrontal brain activity with fMRI neurofeedback in healthy subjects and patients with posttraumatic stress disorder - NF_PTSD2

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006109

Enrollment

Registered

2014-05-30

Start date

2014-10-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F43.1

Interventions

Group 1: Patients with posttraumatic stress disorder will absolve a training of 1hour, in which they will train to regulate brain activity by means of the strategy of cognitive reappraisal. In two run

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: PTSD according to SKID diagnosis F43.1 as well as healthy subjects without any psychiatric diagnosis For all subjects: -Age: 18 - 75 years -right-handed (Edinburgh Handedness Inventory, criterion: min. 8 out of 10 items; Oldfield, 1971) -proficient knowledge of the German language

Exclusion criteria

Exclusion criteria: -pregnancy or lactation period, -traumatic brain injury, -neurologic or acute somatic diseases, -known internistic (e.g. metabolic, endocrine or cardiac) dysfunction, -contraindications - including relative contraindications - regarding MRI-research such as magnetic metal implants (also intrauterine device), -extensive tattoos or claustrophobia, -non-existent or diminished responsibility of the patient -any substance dependence -severe affective disorders -multiple traumatisation since childhood/youth

Design outcomes

Primary

Measure	Time frame
By means of functional magnetic resonance imaging (fMRI) measured activity in the amygdala and DLPFC (dorsolateral prefrontal cortex) in response to aversive pictures during cognitive reappraisal with versus without neurofeedback in patients with PTSD (post-traumatic stress disorder) and healthy subjects	—

Secondary

Measure	Time frame
Changes in Mood as measured by the Positive and Negative Affect Scale, expanded version (PANAS-X) before and after the Training and changes in PTSD severity as measured by Essener Trauma Inventory (ETI). The PANAS-X measures affect of 2 scales (positive and negative) and has several subscales for the discrete emotions. The ETI measures intensity of PTSD symptomatology on the scales Intrusion, avoidance, hyperarousal and dissociation.	—

Measure

Time frame

Changes in Mood as measured by the Positive and Negative Affect Scale, expanded version (PANAS-X) before and after the Training and changes in PTSD severity as measured by Essener Trauma Inventory (ETI). The PANAS-X measures affect of 2 scales (positive and negative) and has several subscales for the discrete emotions. The ETI measures intensity of PTSD symptomatology on the scales Intrusion, avoidance, hyperarousal and dissociation.

—

Countries

Germany

Contacts

Public ContactJana Zweerings

Klinik für Psychiatrie, Psychotherapie und Psychosomatik, RWTH Aachen University

jzweerings@ukaachen.de0241 8088378

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026