Cerebral hemodynamics after brachytherapy in pediatric patients with supratentorial low-grade astrocytoma or optic pathway glioma in patients with and without neurofibromatosis type I

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006080

Enrollment

Registered

2014-04-17

Start date

2014-09-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Y84.2 (ICD10) Radiological procedure and radiotherapy D33.0 Q85.0 I67.9

Interventions

Group 1: Cerebral autoregulation (phase and gain) and neurovascular coupling (rate time, natural frequency, attenuation, gain) and simultaneous recording of visually-evoked potential (latency and ampl

Eligibility

Sex/Gender

All

Age

6 Years to 25 Years

Inclusion criteria

Inclusion criteria: 1.Children and young adults (age 6-25 years) with (patients) or without (control) a history of interstitial cerebral radiotherapy ("Seed") during childhood due to a supratentorial low-grade astrocytoma or glioma of the optic pathway 2. Written informed consent to the study by the patient/proband or accordingly the person having the care and custody of the child.

Exclusion criteria

Exclusion criteria: 1. No ultrasound window for transtemporal ultrasound. 2. history of external irradiation of the brain

Design outcomes

Primary

Measure	Time frame
Single-time dopplersonographic ultrasound examination of cerebral autoregulation (Phase und Gain) as well as neurovascular coupling (rate time, natural frequency, attenuation, gain) and basic parameters of cerebral hemodynamics (pulsatility index, cerebral blood flow velocities of middle and posterior cerebral artery) at study inclusion.	—

Secondary

Measure	Time frame
At study inclusion, cinical data regarding diagnosis and treatment of the brain tumor, presence of neurofibromatosis type 1 and regarding cerebral vasculopathy, cerbrovascular events and cardiovascular risk factors will be assessed by a questionnaire. Clinical data will be correlated with the parameters of cerebral hemodynamics. Visually-evoked potentials are correlated with the parameters of neurovascular coupling.	—

Measure

Time frame

At study inclusion, cinical data regarding diagnosis and treatment of the brain tumor, presence of neurofibromatosis type 1 and regarding cerebral vasculopathy, cerbrovascular events and cardiovascular risk factors will be assessed by a questionnaire. Clinical data will be correlated with the parameters of cerebral hemodynamics. Visually-evoked potentials are correlated with the parameters of neurovascular coupling.

—

Countries

Germany

Contacts

Public ContactWibke Janzarik

Zentrum für Kinder- und Jugendmedizin, Abteilung für Neuropädiatrie und Muskelerkrankungen

wibke.janzarik@uniklinik-freiburg.de0049 761 270 43000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026