Determination of blood volume and hemoglobin mass using the optimised carbon monoxide rebreathing method in clinical patients - cardiac failure or situation post cardiac transplant

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006078

Enrollment

150

Registered

2014-05-09

Start date

2014-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I50.1 D63.8

Interventions

Group 1: Key population (cross-sectional study part): chronic cardiac failure with at least mildly reduced systolic LV-function (EF= 45%), of various etiologie, e.g. ischemic, dilated, inflammatory. O

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Main study population (cross-sectional analysis): chronic cardiac failure with at least a moderately reduced LV function (EF<45%), of various origin, e.g. ischemic, dilated, inflammatory. Or preserved LV function when situation post heart transplant. Phycial acitivity group (longitudinal analysis): as above but with a weekly physical activity of at least 150min, e.g. through participation in cardiac sports group, nordic walking, strolling

Exclusion criteria

Exclusion criteria: - patients with acute coronary syndrome without intervention - life expectation of less than one year because of a non-cardial disease - current onconlogic disease - acute infection (e.g. pneumonia) - evidence for acute transplant failure - chronic inflammatory diseases - relevant chronic kidney disease of non cardiac origin - anemia of origin other than cardiac e.g. chronic intestinal hemorrhage - [?Hb] < 8g/dl - current use of erythropoietic growth factors - patients featuring a lung function that does not allow participation in a rebreathing procedure from a clinical aspect - people that cannot participate in the study because of a lack of compliance, based on the judgement of the study doctors - chronic alkohol or drug abuse - those who are not able or not willing to give an informed consent to participate in the study

Design outcomes

Primary

Measure	Time frame
Hemoglobin mass measured using the optimised carbon monoxide rebreathing method in patients with different stages of left ventricular failure	—

Secondary

Measure	Time frame
- Influence of physical activity on hemoglobin mass. - Relation between hemoglobin mass and FBC, Iron status	—

Countries

Germany

Contacts

Public ContactTorben Pottgiesser

Uniklinik FreiburgInstitut für Arbeits- und Bewegungsmedizin

torben.pottgiesser@uniklinik-freiburg.de0761 270 74920

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 22, 2026