H2O/O2-PET for determination of tumor hypoxia before and during radiotherapy in patients with head and neck cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00006058

Enrollment

Registered

2014-07-11

Start date

2014-05-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C00-C14

Interventions

Group 1: H2O/O2-PET and biomarker analysis in blood and saliva before and in week 4 of radio(chemo)therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age = 18 years - Signed Informed Consent - 10 patients with histologically proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx - Tumors large enough for PET imaging according to the judgement of the treating physicians - Radio(chemo)therapy or radiotherapy in combination with cetuximab with curative intent

Exclusion criteria

Exclusion criteria: - Induction chemotherapy - Pregnant and lactating women

Design outcomes

Primary

Measure	Time frame
Feasibility of H2O/O2 PET to determine changes in oxygen consumption and tumor hypoxia.	—

Secondary

Measure	Time frame
Applicability of H2O/O2-PET/CT and biomarker analysis for hypoxia-adapted treatment planning, therapy monitoring and prognosis	—

Countries

Switzerland

Contacts

Public ContactOliver Riesterer

UniversitätsSpital Zürich

oliver.riesterer@usz.ch+41 (0)44 255 1111

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026