Contribution of microbially synthesized vitamers to folate status and impact on inflammatory bowel diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006051

Enrollment

Registered

2014-04-22

Start date

2014-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K50

Interventions

Group 1: Ileal Crohn's disease patients with high folate serum Status. The following parameters will be measured: Inflammatory and oxidative stress markers in blood (ELISA), serum folate levels, fec

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: ileal Crohn's disease Patients

Exclusion criteria

Exclusion criteria: 1) Other Gastrointestinal Diseases 2) High consumption of alcohol (21 Portion/week) 3) High Steroid dose (>60 mg/day) 4) Blood thining medicines 5) Expecting or lactating mothers

Design outcomes

Primary

Measure	Time frame
- Difference in the spectrum and concentration of folates in fecal samples in ileal Crohn's disease patients with low and high serum folate status	—

Secondary

Measure	Time frame
- Differences in inflammatory and oxidative stress markers in Crohn's disease patients with low and high serum folate status. - Correlation between microbiota composition and inflammatory/oxidative stress markers - Correlation between microbiota composition and gene variants relevent for folate synthesis.	—

Countries

Germany

Contacts

Public ContactDelphine Saulnier

German Institute of Human Nutrition

delphine.saulnier@dife.de+49 (0)33 200/88-2464

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026