Coronary heart disease I25
Conditions
Interventions
Group 1: Control nights without noise
Group 2: simulated nighttime aircraft noise with 60 events
Sponsors
Univesitätsmedizin Mainz
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Men and women between 30 and 75 years with established cardiovascular diseas or at a Framingham Risk > 10 % (Framingham Heart General CVD Risk , D'Agostino et. al), , who are not exposed to nighttime aircraft noise or other traffic noise exposure > 45 dB at their homes
Exclusion criteria
Exclusion criteria: stroke Nitrates in medication medication changes in last 4 weeks unstable cardiovascular disease (specified in study protocol) hospitalization in the preceding 4 weeks uncontrolled hypertension > 160/100 mmHg severe cardiac valve stenosis or regurgitation severely depresse LVEF Leq 45 dB at place of residence sleep disorders (PSQI > 10) positive Screening for obstructive sleep apnea (OSAS) regular sleep duration 30 dB employees of airports, airline and anti-noise activists
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| difference % absolute of flow-mediated-dilatation (FMD) on the morning after noise and control nights. The measurement is performed by determining the vessel diameter of the brachial artery with linear probe ultrasound before and after 5 minutes of proximal occlusion with a pressure cuff. | — |
Secondary
| Measure | Time frame |
|---|---|
| systolic blood pressure(continous), sleep quality (VAS and Evening-Morning protocol of the German societey of sleep medicine DGSM) Pulse transit time (Somnowatch during study nights) adrenaline (concentration on the morning after study nights) HRV (contiously Somnowatch) HF (continously Somnowatch) | — |
Countries
Germany
Contacts
Public ContactHannelore Seiler
Universitätsmedizin Mainz
Outcome results
None listed