Pharmacogenetics of antibiotics during cardiac surgery with cardiopulmonary bypass

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00006047

Enrollment

Registered

2014-04-03

Start date

2014-04-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I35

Interventions

Group 1: Tissue antibiotic concentration (substernal fat tissue, pericardium and aortic valve) in 20 patients undergoing elective aortic valve surgery. Tissue antibiotic concentration will be evaluate

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Elective cardiac surgery for aortic valve replacement

Exclusion criteria

Exclusion criteria: Age <18 years; Patient refusal

Design outcomes

Primary

Measure	Time frame
Primary endpoint of the study is to evaluate antibiotic drug concentrations in patients tissue and serum and to explore the minimal inhibition concentration for grampositive and gramnegative pathogens in the respective samples.	—

Countries

Germany

Contacts

Public ContactChristoph Sponholz

Klinik für Anästhesiologie und IntensivmedizinUniversitätsklinikum Jena

christoph.sponholz@med.uni-jena.de03641 - 9322225

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026