Development, validation and clinical use of the dynamic pruritus score (DPS)

Development, validation and clinical use of the dynamic pruritus score (DPS) - PruDPS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005970

Enrollment

162

Registered

2014-04-15

Start date

2010-10-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L29.9

Interventions

Group 1: Patients with chronic pruritus (n=102) will be asked to fill out questionnaires at two time points (day 1 and day 14) on quality of life, intensity of pruritus and changes in skin. With the h

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age >18, male and female, out- and in-patients with atopic dermatitis, urticaria, prurigo nodularis and chronic pruritus. The patients received a topical therapy (between V1 and V2) during the study for 2 weeks.

Exclusion criteria

Exclusion criteria: Age below 18 years, pregnancy, breastfeeding, active psychosomatic and psychiatric disorders, known active malignant underlying diseases, previous studies within the last 4 weeks, drug use, drug abuse, topical application of tacrolimus, pimecrolimus, polidocanol, menthol, cannabinoid agonists or capsaicin within the last 2 weeks prior to the study, systemic administration of steroids, cyclosporine A and other immunosuppressive agents, naltrexone, UV therapy within the last two weeks before the study start, systemic administration of antihistamines, topical steroids within one week prior to the study, acute exacerbation or cutaneous infections in atopic dermatitis

Design outcomes

Primary

Measure	Time frame
Calculation of correlation coefficients of the PruDPS (dynamic pruritus score) with VAS. The calculation is based on the indication of a change in pruritus from day 1 to day 14.	—

Secondary

Measure	Time frame
Correlation of PruDPS with other intensity scales (VAS "today," VAS "average last four weeks," VAS "worst last four weeks," NRS "today," VRS "today") based on the Neuroderm questionnaire, survey the quality of life by DLQI and HADS, PBI-P, histamine intrakutan testing, neurometer stimulation, corneometry, EQ-5D. The collection of data is done on day 1 (V1) and day 15 (V2). The DPS is assessed at the 2nd visit on day 15 by means of the scale-smiley-bar and the retro-VAS	—

Measure

Time frame

Correlation of PruDPS with other intensity scales (VAS "today," VAS "average last four weeks," VAS "worst last four weeks," NRS "today," VRS "today") based on the Neuroderm questionnaire, survey the quality of life by DLQI and HADS, PBI-P, histamine intrakutan testing, neurometer stimulation, corneometry, EQ-5D. The collection of data is done on day 1 (V1) and day 15 (V2). The DPS is assessed at the 2nd visit on day 15 by means of the scale-smiley-bar and the retro-VAS

—

Countries

Germany

Contacts

Public ContactSabine Stoll

Klinik für Hautkrankheiten, Kompetenzzentrum chronischer Pruritus (KCP)Universitätsklinikum Münster

juckreizambulanz@ukmuenster.de0251-8357470

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026