N18.3 N18.4 N18.5
Conditions
Interventions
Group 1: Ambulatory or stationary patients with chronic kidney diseases in stage 3-5. A venous blood sample will be obtained and clinical and demographic data will be recorded.
Group 2: Healthy contro
Sponsors
Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: CKD patients in stage 3-5, with last dialysis >48h
Exclusion criteria
Exclusion criteria: 1 Age <18 years 2 pregnancy 3 Immunosuppressive therapy (within the last 7 days) 4 Acute kidney injury 5 Dialysis in the past 48 hours 6 Major hematologic pre-existing conditions 7 Known HIV infection. 8 acute or chronic inflammation 9 State after organ transplantation 10 Known autoimmune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rolling velocity and arrest of leukocyte in ex vivo flow chamber experiments | — |
Secondary
| Measure | Time frame |
|---|---|
| The influence of chronic uremia on the intracellular signal transduction in activated leukocytes is investigated by biochemical assays (western blot). Expression of adhesion molecules on the surface of isolated neutrophils is analyzed by flow cytometry. Demographic and clinical data are collected and analyzed in order to accurately describe the disease severity and progression of chronic kidney injury (laboratory data, general infectious monitoring, monitoring of renal replacement therapy). | — |
Countries
Germany
Contacts
Public ContactAlexander Zarbock
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie Universitätsklinikum Münster
Outcome results
None listed