STrain and support in Early Pregnancy: Onward Neonatal Epigenetic effects (STEP ONE)

STrain and support in Early Pregnancy: Onward Neonatal Epigenetic effects (STEP ONE) - STEP ONE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005741

Enrollment

150

Registered

2014-02-21

Start date

2013-12-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnant women undergoing amniocentesis due to medical reasons

Interventions

Group 1: There will be no intervention. We will compare extreme groups with regard to perceived stress, psychopathology and social stressors. The dependent variable is the methylation of the infant's

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: pregnant women, amniocentesis for medical reasons

Exclusion criteria

Exclusion criteria: severe genetic findings, severe disability of the child, insufficient german language, impaired ability to consent, multiples

Design outcomes

Primary

Measure	Time frame
Relationship between strain, psychological features and social support of the pregnant women (measured with questionnaires and interview) and epigenetic features of the infant (DNA methylation in cells of amniotic fluid and cord blood).	—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026