Y84.2 Radiological procedure and radiotherapy C71 I67.9
Conditions
Interventions
Group 1: Cerebral autoregulation (phase and gain) and neurovascular coupling (resting flow velocity, overshoot flow velocity, steady-state flow velocity) of children and young adults with history of r
Sponsors
Zentrum für Kinder- und Jugendmedizin, Abteilung für Neuropädiatrie und Muskelerkrankungen
Eligibility
Sex/Gender
All
Age
6 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Children and young adults (age 6-35 years) a) with a history of cerebral radiotherapy during childhood due to a posterior fossa brain tumor (patients) b) age-matched healthy children and young adults (control). 2. patients: in remission, time interval to last chemotherapy and radiotherapy at least 12 months. 3. Written informed consent to the study by the patient/proband or accordingly the person having the care and custody of the child.
Exclusion criteria
Exclusion criteria: 1. No ultrasound window for transtemporal ultrasound. 2. controls: Disease of central nervous system, history of chemotherapy of radiotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-time dopplersonographic ultrasound examination of cerebral autoregulation (phase and gain) as well as neurovascular coupling (resting flow velocity, overshoot flow velocity, steady-state flow velocity) at study inclusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| At study inclusion, cinical data regarding cerebral vasculopathy, cerbrovascular events and cardiovascular risk factors will be assessed by a questionnaire. Clinical data will be correlated with the parameters of cerebral hemodynamics. | — |
Countries
Germany
Contacts
Public ContactWibke Janzarik
Zentrum für Kinder- und Jugendmedizin, Abteilung für Neuropädiatrie und Muskelerkrankungen
Outcome results
None listed