glucose homeostasis
Conditions
Interventions
Group 1: Healthy volunteer
50g whey protein
50g maltodextrin19
10g lactulose
2g Hydroxyproline
vanilla- or lemonflavour
solved in 300ml water
Group 2: Healthy volunteer
50g casein
50g maltodextrin19
1
Sponsors
Kraft Foods R&D Inc.Zweigniederlassung München
Eligibility
Sex/Gender
All
Age
20 Years to 74 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy volunteers: -age between 20 and 50 years -BMI 20 up to 28 kg/m2 -written consent Inclusion criteria for prediabetic volunteers: -age between 20 and 50 years -confirmation of the prediabetic state corresponding to the definition of the WHO. ( Glucose tolerance test: baseline/fasting state = 6,1 mmol/l (= 110 mg/dl) and < 7,0 mmol/l (< 126 mg/dl) in venous plasma or = 5,6 mmol/l (= 100 mg/dl) and < 6,0 mmol/l (< 109 mg/dl) in capillary whole blood and/or 2 hour sample = 7,8 mmol/l (= 140 mg/dl) and <11,1 mmol/l (< 200 mg/dl) in venous plasma or capillary whole blood -written consent Inclusion criteria for diabetic patients: -age up to 74 years -single Metformin therapy -written consent
Exclusion criteria
Exclusion criteria: Exclusion criteriy for healthy volunteers: -chronic diseases e.g. diabetes mellitus, inflammatory diseases, cardiovaskular diseases, infectious diseases -severe depression -known drug- and alcoholabuse -medication -smoker Exclusion criteria for prediabetic volunteers: -chronic diseases e.g.iinflammatory diseases, cardiovaskular diseases, infectious diseases -severe depression -known drug- and alcoholabuse -medication -smoker Exclusion criteria for diabetic patients: -severe depression -known drug- and alcoholabuse -smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemocue: glucose Multiplex: insulin,GIP, C-peptides, glucagon Elisa: GLP-1 time span: up to 240 min after intake in the fasting state reading points: 0, 15, 30, 45, 60, 90, 120, 180, and 240 min | — |
Secondary
| Measure | Time frame |
|---|---|
| LC-MS/MS: acetaminophen, amino acids, acylcarnitine Multiplex: ghrelin Spectrometer: superoxiddismutase, catalase, glutathionreductase, dipeptidylpeptidase IV, ß-hydroxybutyrate, non esterified free fatty acids visual analogue scale feeling of hunger time span: up to 240 min after intake in the fasting state reading points: 0, 15, 30, 45, 60, 90, 120, 180, and 240 min reading points for visual analogue scale: every 30 min reading points forSOD, catalase, glutathione reductase: 0, 30, 240 min | — |
Countries
Germany
Contacts
Public ContactAnja Höfle
Wissenschaftszentrum WeihenstephanLehrstuhl für ErnährungsphysiologieTechnische Universität München
Outcome results
None listed