Hen's Egg Allergy Prevention Study

Hen's Egg Allergy Prevention Study - HEAP Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00005668

Enrollment

800

Registered

2014-01-28

Start date

2008-06-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hen's egg allergy T78.1 T78.0 L20.9 J45.9

Interventions

Group 1: Children will receive verum (2.5 g of hen's egg protein) three times a week starting after 4 months of age once weaning has commenced until 12 months of age. All children will be otherwise o

Eligibility

Sex/Gender

All

Age

No minimum to 4 Months

Inclusion criteria

Inclusion criteria: birth of baby of > 35 weeks gestational age, birth weight > 2,5 kg, sufficient knowledge of German language

Exclusion criteria

Exclusion criteria: birth of baby of < 35 weeks gestational age, birth weight < 2,5 kg

Design outcomes

Secondary

Measure	Time frame
IgE-mediated hen's egg allergy at the age of 1 year confirmed by double blind placebo controlled oral hen's egg challenge in all children with hen's egg-specific IgE levels >0.35 kU/l (see primary endpoint).	—

Primary

Measure	Time frame
Sensitization to hen's egg protein at the age of 12 months will be determined through measurement of hen's egg-specific serum IgE (ImmunoCAP FEIA) at 12 months of age.	—

Countries

Germany

Contacts

Public ContactIngrid Lawnitzak

Charité Universitätsmedizin Berlin, Pädiatrie m. S. Pneumologie und Immunologie, Kinderallergologisches Studienzentrum

kinder-allergiestudien@charite.de+49-(0)30-450 566428

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026