In vivo assessment of membraneexcitability changes due to Propofolmedication in motor nerve and skelettmuscle

In vivo assessment of membraneexcitability changes due to Propofolmedication in motor nerve and skelettmuscle - Pro-TROND

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005661

Enrollment

Registered

2014-11-14

Start date

2014-11-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy patients (ASA I and II) with planed, small operation

Interventions

Group 1: Arm 1 - membrane excitability testing with "threshold tracking" in motor nerve before and after Propofol administration Group 2: Arm 2 - membrane excitability testing with "threshold tracking

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: planed operation with Propofol anesthesia

Exclusion criteria

Exclusion criteria: neuro-muscular diseases

Design outcomes

Primary

Measure	Time frame
Membraneexcitability changes assessed by "Threshold tracking" of motor nerve / muscle fibres before and after Propofol administration	—

Secondary

Measure	Time frame
Concentration of electrolytes before and after administration of Propofol. Propofolconcentration after induction of anesthesia. Korrelation with membraneexcitability changes in motor nerve / muscle fibres before and after Propofoladministarion.	—

Countries

Germany

Contacts

Public ContactSusanne Koch

Charité Campus Virchow-Klinikum

susanne.koch@charite.de030 450651808

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026