Peripartal Coagulation -Impact of prepartum concentration of fibrinogen on the clot formation and the thromboelastometry derived parameters (ROTEM®) with regard to the partal blood loss

Peripartal Coagulation -Impact of prepartum concentration of fibrinogen on the clot formation and the thromboelastometry derived parameters (ROTEM®) with regard to the partal blood loss - PepCo

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005624

Enrollment

200

Registered

2014-02-13

Start date

2012-09-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peripartal coagulation, post partum haemorrhage (PPH) PPH in combination with fibrinogen concentration, parameters of plasmatic coagulation and partal blood loss O72

Interventions

Group 1: - women with vaginal delivery and a partal blood loss 500 ml

- Fibrinogen levels (measured according to Clauss) and parameters of ROTEM® (thromboelastometry, TEM® Munich, Germany) are measured prepartum at admission to the delivery ward (generally < 24 h befor

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - pregnant women at admission to the labor ward for vaginal delivery - minimum age 18 years - consent of women for use of personal data

Exclusion criteria

Exclusion criteria: - not able to speak and understand german - doubt of ability to judge

Design outcomes

Primary

Measure	Time frame
1. Prepartal determination of Maximum Clotting Formation (MCF) in the Fibtem® test (ROTEM® ,TEM, München) and fibrinogen concentration (measured according to Clauss) 2. Intrapartum measurement of blood loss systematically by a calibrated drape under buttocks (Brenner Medical, München)	—

Secondary

Measure	Time frame
1. Determination of MCF in the Fibtem® test (ROTEM® analysis) and fibrinogen concentration after delivery and 48 h postpartum 2. Determination of Clotting Time (CT) and Clotting Formation Time (CFT) in the INTEM® test (ROTEM® analysis) pre- and postpartal (after delivery and 48h postpartum) 3. Different viscoelastic parameters ( CT, CFT, alpha angle ) of ROTEM® analysis (INTEM®, EXTEM®, APTEM®)	—

Measure

Time frame

1. Determination of MCF in the Fibtem® test (ROTEM® analysis) and fibrinogen concentration after delivery and 48 h postpartum 2. Determination of Clotting Time (CT) and Clotting Formation Time (CFT) in the INTEM® test (ROTEM® analysis) pre- and postpartal (after delivery and 48h postpartum) 3. Different viscoelastic parameters ( CT, CFT, alpha angle ) of ROTEM® analysis (INTEM®, EXTEM®, APTEM®)

—

Countries

Germany

Contacts

Public ContactLutz Kaufner

Charitè Universitätsmedizin BerlinKlinik für Anästhesiologie m.S. operative Intensivmedizin

lutz.kaufner@charite.de030-450651026

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026