locally advanced adenocarcinoma of the stomach or gastroesophageal junction (AEG I-III) C16
Conditions
Interventions
Group 1: Preoperative combined aerobic exercise and strength training during neoadjuvant Chemotherapy for 10-12 weeks. Training occurs in 2 phases:
- supervised exrcise training: twice weekly under su
Sponsors
Klinikum rechts der Isar der TU München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.) Histologically verified, resectable Adenocarcinoma of the stomach or the esophageal-gastric-junction (AEG I-III), stage uT2 - uT4 without distant metastases. 2.) age = 18 years 3.) 3.) ECOG Status 0-2 4.) negative pregnancy test for women of childbearing-potential 5.) Sufficient bone-marrow, hepatic and renal function by assessment of the treating oncologist
Exclusion criteria
Exclusion criteria: 1.) non-resectable primary tumour by assessment of the treating surgeon. 2.) Participation in an interventional trial with interefering primary endpoint. 3.) pregnancy or breat-feeding 4.) severe cardiac comorbidities (instable angina pectoris, congestive heat failure NYHA IV, malignent arteriell Hypertension). 5.) severe pulmonary comorbidities (COPD GOLD IV) 6.) Muscoloskeletall comorbidities (e.g. coxarthritis, Gonarthritis) that significantly limit mobility 7.) lack of compliance 8.) other reasons that impede physical exercise training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Morbidity and Mortality according to Dindo-Clavien Grade II-IV | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.) number of patients enrolled within the recruiting period 2.) number of screened patients 3.) Number of patients that finish the exercise training (compliance) 4.) drop-out rate | — |
Countries
Germany
Contacts
Public ContactAndre L. Mihaljevic
Klinikum rechts der Isar,Technische Universität München
Outcome results
None listed