acute respiratory tract infections hepatic infection J00-J06 B90-B94 K70-K77
Conditions
Interventions
Group 1: Pediatric patients aged between 1 and 18 years.
For quantification of liver enzymes (ASAT, ALAT, Gamma-GT, alkaline phosphatase, bilirubin (total, direct and indirect) and albumin) blood samp
Sponsors
Klink für Kinder und JugendmedizinEVK Hamm
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients between 1 and 18 years old. 2. Diagnosis of uncomplicated upper or lower respiratory tract infection (rhinitis, sinusitis, pharyngitis, bronchitis, interstitial or central pneumonia). Diagnosis of pneumonia not exceeding 30% of included patients. 3. Written informed consent of patients and their parents. 4. For hospitalized patients blood sampling and nasal lavage should take place within 24 hours after hospital admission.
Exclusion criteria
Exclusion criteria: 1. Severe infections requiring assisted respiration or circulatory support via drug therapy. 2. Known or suspected congenital malformation or metabolic dysfunction which may influence study results. 3. Bronchopneumonia, pleuropneumonia and segmental pneumonia. 4. Infections already existing for more than five days. 5. Pre-existing icterus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of the frequency of liver involvement during acute respiratory tract infections in pediatric patients. Blood sampling at study entry and 3-7 days later for quantification of serum levels of liver enzymes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Which viruses are mainly responsible for the respiratory infections? Which viruses may cause hepatic infection? Identification of viral pathogens by means of PCR (Polymerase-Chain-Reaction). | — |
Countries
Germany
Contacts
Public ContactWolfgang Kamin
Klinik für Kinder und Jugendmedizin am EVK Hamm
Outcome results
None listed