Long-term sequelae after severe sepsis: cognitive impairments and structural changes in the brain, an MRI study

Long-term sequelae after severe sepsis: cognitive impairments and structural changes in the brain, an MRI study - LossCog-MRI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005484

Enrollment

Registered

2013-12-12

Start date

2013-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41 R57.2

Interventions

Group 1: Sepsis-survivors: Cognitive Testing: a) DemTect and Clock drawing test

b) Verbal Learning and Memory Test (VLMT, Helmstaedter, Lendt und Lux, Beltz Test GmbH, Göttingen 2001) declarative verbal memory (learning and long-term encoding and retrieval)

c) Testbatterie für Aufmerksamkeitsprüfung (TAP), Alertness: tonic alertness, maintenance of a high level of reaction and capacity over a long time, Go/No-Go: suppression of unwanted reactions, split

atrophies/ changes in brain volumes, resting state, fMRI MEG: resting activity with eyes open/ closed (hallmark for global brain function)

frequency entrainment characterized by the global similarity index (GSI)

measure for the synchronization of brain regions Group 2: Healthy controls: Cognitive Testing: a) DemTect and Clock drawing test

measure for the synchronization of brain regions

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Sepsis patients: Survivors of severe sepsis/ septic shock; male and female adults aged between 18-65 years; Written informed consent; former sepsis patients with an IQCODE > 2,29; Former sepsis patients who requested help of the German Sepsis Aid between 2011 and 2013 Normal healthy controls: male and female adults aged between 18-65 years; Written informed consent

Exclusion criteria

Exclusion criteria: stroke or other severe CNS disorders; epilepsy; cardiac pacemaker, defibrillator and other electromagnetic devices; Liver cirrhosis; amaurosis; current intake of neuroleptics/ antidepressants; acute claustrophobia; pregnancy; participation in another study

Design outcomes

Primary

Measure	Time frame
characterization of structural changes in the brain via fractional anisotropy; voxel based morphometry of the amygdala/ hippocampus	—

Secondary

Measure	Time frame
Correlation between cognitive outcomes (TAP/ DemTect) and MEG parameters; Structural changes in the brain in terms of fiber damages; change of functional connectivity in former sepsis patients	—

Countries

Germany

Contacts

Public ContactTheresa Götz

Hans-Berger-Klinik für Neurologie Universitätsklinikum Jena

theresa@biomag.uni-jena.de+49 3641 9325780

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 20, 2026