Mycotic findings in patients after liver transplantation – Invasive mycosis or harmless colonization?

Conditions

Patients undergoing orthotopic liver transplantation from deceased donors C22.0 K74.6

Sebastian Decker, Dagmar Hildebrand, Thomas Brückner, Christoph Lichtenstern, Klaus Heeg et al. (8 authors)

Diagnostics2020-10-316 citations

Soluble intercellular adhesion molecule (ICAM)-1 detects invasive fungal infections in patients following liver transplantation

Sebastian Decker, Anne Incamps, Henryk Wilk, Florian Uhle, Thomas Brückner et al. (12 authors)

Biomarkers2020-08-193 citations

10.1080/1354750x.2020.1810318

New approaches for the detection of invasive fungal diseases in patients following liver transplantation-results of an observational clinical pilot study.

Decker SO, Krüger A, Wilk H, Grumaz S, Vainshtein Y, Schmitt FCF, Uhle F, Bruckner T, Zimmermann S, Mehrabi A, Mieth M, Weiss KH, Weigand MA, Hofer S, Sohn K, Brenner T.

2019-03-0516 citations

10.1007/s00423-019-01769-y

Interventions

Group 1: 100 patients following liver transplantation will be included. The following parameters will be screened on day 0-1-2-7-14-21-28 after transplantation: Anamnesis (acute/chronic), general infe

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Liver transplantation at the center of transplantation in Heidelberg • Written and signed informt consens • Age > 18 years

Exclusion criteria

Exclusion criteria: Non-Compliance to the including criteria’s

Design outcomes

Primary

Measure	Time frame
Incidence, risk factors and progress of mycotic infections in patients with liver transplantation.	—

Secondary

Measure	Time frame
Assessment of the additional benefit of a next-generation sequencing (NGS)-based diagnostic approach, the diagnostic value of ß-D-glucan (BG), galactomannan (GM), interferon gamma (INF-?), tumor necrosis factor alpha (TNF-a), interleukins (IL)-2, -4, -6, -10, -17A and mid-regional proadrenomedullin (MR-proADM) for the diagnosis of an invasive fungal disease	—

Countries

Germany

Contacts

Public ContactStefan Hofer

Klinik für Anaesthesiologie Universitätsklinikum Heidelberg

stefan.hofer at med.uni-heidelberg.de+49 (0) 6221-56 377 87

Outcome results

None listed