Physiologic changes of cardiocirculatory parameters in normobaric hypoxia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005459

Enrollment

Registered

2013-11-21

Start date

2013-11-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mountain sickness Healthy volunteers T70.2

Interventions

Group 1: All subjects will undergo a baseline measurement followed by exposition to normobaric hypoxia in two steps (4000m, 5500m). An exercise challange at the end is optional.

Eligibility

Sex/Gender

Male

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Willingness to participate

Exclusion criteria

Exclusion criteria: Signifikant morbidity in the past

Design outcomes

Primary

Measure	Time frame
3D-Echokardiography (Torsion and Twist of left and right ventricle, PA-pressure, Vitien. Measurements Basleline and 5500m). Laser-doppler (flow profiles, Fourier-Analysis: Baseline and 5500m), Laboratory values (blood count, Cytokines, BNP, Troponin, thrombocyte function; baseline, 4000 and 5500m), Count of circulating regulatory T-cells (Baseline, 5500m), dendritic cells (Baseline, 5500m), Metabolomics (Baseline, 4000m, 5500m), Protein expression of erythrocytes (Basleline, 4000m, 5500m). Retinal vessel analysis (Baseline, 5500m).	—

Measure

Time frame

3D-Echokardiography (Torsion and Twist of left and right ventricle, PA-pressure, Vitien. Measurements Basleline and 5500m). Laser-doppler (flow profiles, Fourier-Analysis: Baseline and 5500m), Laboratory values (blood count, Cytokines, BNP, Troponin, thrombocyte function; baseline, 4000 and 5500m), Count of circulating regulatory T-cells (Baseline, 5500m), dendritic cells (Baseline, 5500m), Metabolomics (Baseline, 4000m, 5500m), Protein expression of erythrocytes (Basleline, 4000m, 5500m). Retinal vessel analysis (Baseline, 5500m).

—

Countries

Germany

Contacts

Public ContactChristian Jung

Universitätsklinikum Jena

christian.jung@med.uni-jena.de036419324559

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026