Influence of individual hemolysis, haptoglobin- genotype and CD 163 Receptor-activity on acute kidney injury in cardiac surgery patients.

Influence of individual hemolysis, haptoglobin- genotype and CD 163 Receptor-activity on acute kidney injury in cardiac surgery patients. - Hp-AKI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005457

Enrollment

150

Registered

2013-11-26

Start date

2013-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N17.9 Z95.1

Interventions

Group 1: During cardiac surgery with cardio-pulmonal-bypass, acute kidney injury can occur. With this Trial one aspect of kidney injury by hemolyis will be examined. For this purpose blood probes wil

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Aorto-coronare Bypass surgery

Exclusion criteria

Exclusion criteria: Extracorporale membranoxygenation, kidney failure requiering dialysis aortokoronare Bypass-surgery in combination with impossible consent Information, incomplete datasets

Design outcomes

Primary

Measure	Time frame
Bloodprobes for determination of Haptoglobin and free hemoglobin concentration preoperative (after anesthesia induction), intraoperative (Start and End) and postoperative (surgery-day and day 1) Analysis of haptoglobin Genotyp and CD 163 receptor acitivity.	—

Secondary

Measure	Time frame
Acute kidney injury day one to five according to AKIN Criteria (diureses and Serum creatinine) and evaluation of the concentration of the biomarkers TIMP-2 and IGFBP-7.	—

Countries

Germany

Contacts

Public ContactAnna Wetz

Universitätsmedizin Göttingen

anna.wetz@med.uni-goettingen.de00495513922995

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 5, 2026