haemochromatosis E83.1 M15-M19
Conditions
Interventions
Group 1: The following patients' groups undergo ultrasound examination of 38 joints:
1) patients with hereditary hemochromatosis associated arthropathy
2) patients with hereditary hemochromatosis wit
Sponsors
Medizinische Universität Graz
Eligibility
Sex/Gender
All
Age
18 Years to 89 Years
Inclusion criteria
Inclusion criteria: Male or female patient =18 years and <90 years of age HH (with or without arthropathy) as defined below OR hand OA as defined by the American College of Rheumatology (ACR) criteria without evidence of HH
Exclusion criteria
Exclusion criteria: Current treatment with any investigational drug Complete destruction of joints to be investigated by sonography
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint inflammation is detected more often by ultrasound [defined as synovial hypertrophy and/or effusion (SH/E) by B-mode and/or hypervascularisation by Power Doppler (PD)] than by clinical examination (defined as synovial swelling) in patients with HH arthropathy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Joint inflammation as indicated by ultrasound correlates with pain levels (measured by a visual analogue scale ranging from 0-100mm), the number of tender joints and restriction of functionality as measured by the health assessment questionnaire 2. Ultrasound more frequently detects structural lesions (erosions and/or osteophytes) than conventional x-ray 3. Inflammatory and structural lesions at hand and finger joints detected by sonography in HH arthropathy patients differ from those of HH patients without arthropathy and hand OA patients | — |
Countries
Austria
Contacts
Public ContactChristian Dejaco
Medizinische Universität Graz
Outcome results
None listed