Patients who must undergo an operation in general anesthesia with midazolam premedication
Conditions
Interventions
Group 1: Determination of Midazolam-plasma level
Sponsors
Institut für Anästhesie und IntensivmedizinKantonsspital Frauenfeld
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: planned operation in general anesthesia, midazolam premedication indicated according to internal standard
Exclusion criteria
Exclusion criteria: Allergy to benzodiazepines, respiratory insufficiency, myasthenia, OSAS, psychiatric disorder, hepatic and/or renal insufficiency, pregnancy or breast feeding, sedating and/or enzym-relevant medication, BMI > 40, severe gastro-intestinal illness, need for benzodiazepines intraoperative
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Midazolam plasma Levels before induction of anesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| Midazolam plasma levels at end of anesthesia, sedation scores (RAAS 0-20) and BIS score when arriving in OR, patient satisfaction (VAS 0-10) the next day. | — |
Countries
Switzerland
Contacts
Public ContactAlexander Dullenkopf
Institut für Anästhesie und IntensivmedizinKantonsspital Frauenfeld
Outcome results
None listed