Role of tonsilar epithelium in oral tolerance

Role of tonsilar epithelium in oral tolerance - The role of human tonsilar epithelium in tolerance induction

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005424

Enrollment

Registered

2014-04-29

Start date

2014-05-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergien T78.4

Interventions

Group 1: Children with allergies: We will compare the composition of T cells and epithelial cells by FACS and by immunofluorescence. As a prerequisite we will need a serum allergy test. We will only i

Eligibility

Sex/Gender

All

Age

1 Years to 17 Years

Inclusion criteria

Inclusion criteria: Enclosed will be children, aged 1 to 17 years, both sexes, which have to undergo tonsillectomy or adenotomy of medical reasons.

Exclusion criteria

Exclusion criteria: Disclosed will be children whose tonsils or adenoids are inflammed or show cysts or malignancies.

Design outcomes

Primary

Measure	Time frame
Frequency and composition of Treg, structure and amount of tonsilar E-Cadherin in tonsilar epithelial cells by FACS and by immunofluorescence	—

Secondary

Measure	Time frame
proliferation of T-cells with and without regulatory T cells	—

Countries

Germany

Contacts

Public ContactHolger Meinicke

Zentrum für Kinder- und Jugendmedizin der Universitätsklinik Freiburg

holger.meinicke@uniklinik-freiburg.de+49 761 270 43000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026