E55.9 E55
Conditions
Interventions
Group 1: Oral supplementation with 1000 IU vitamin D3 per day (Vigantoletten, Merck) after diagnosed vitamin D deficiency, defined as Serum 25 OH D = 50 nmol/l (= 20 ng/mL). Supplementation starts bet
Sponsors
Institut für Ernährungswissenschaft, JLU Giessen
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Pregnant women at the Age of 18 until the Age of 40 years that are going to deliver their Baby at the St. Josefs Hospital Giessen, University Hospital Giessen or Asklepios Hospital Lich
Exclusion criteria
Exclusion criteria: Serum 25 OH D > 125 nmol/L, calcium > 2,65 mmol/L hypercalzemia, primary hyperparathyroidism, pre-pregnancy thyroid disease, sarcoidosis, tuberculosis and other diseases of the granula, kidney disease, fat malabsorption, Coeliac disease, ulcerative colitis, Crohn's disease, exocrine pancreatic insufficiency, vitamin D-receptor defect, anticonvulsant therapy, glucocorticoid intake, heparin therapy to prevent thrombophilia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25-hydroxyvitamin D level in the first, second and third trimester of pregnancy and in cord blood | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal serum 1,25(OH)2D3, parathyroid hormone, alkaline phosphatase and calcium level in the second and third trimester. Pre-pregnancy BMI, physical activity, sunlight exposure, skin pigmentation. Gestationals diabetes, pre-eclampsia, bacterial vaginosis and gestational age. Length of the femur in the second and third trimester of pregnancy, birth weight and high, APGAR score after 1, 5 and 10 minutes, reason for neonatal care, if necessary. | — |
Countries
Germany
Contacts
Public ContactCatrin Würtz
Institut für Ernährungswissenschaft
Outcome results
None listed