stress I25
Conditions
Interventions
Group 1: In our study, we use a mental stress task that can be performed during functional magnetic resonance Imaging of the brain. Main outcome measures include increases in subjective stress level,
Sponsors
Zentralinstitut für Seelische Gesundheit
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: written informed consent
Exclusion criteria
Exclusion criteria: 1. evidence of overt CHD 2. active or uncontrolled physical or mental disorders 3. use of betablockers or steroids 4. disorders or issues prohibiting MRT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in subjective stress level, measured by visual analogue scale immediately before and after stress exposure. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Increase of saliva cortisol concentration associated with mental stress exposure, measured by immunoassay immediately before and 30 minutes after stress exposure 2. Experimental versus control contrast in pACC activity associated with mental stress exposure, measured by fMRI, as compeared to a control condition (cognitive challenge without stress exposure). The stress paradigm uses a block design with repeated 60 seconds task (or control) blocks that are preceded by 5 seconds instruction phase and followed by 20 seconds pause. | — |
Countries
Germany
Contacts
Public ContactFlorian Lederbogen
Zentralinstitut für Seelische Gesundheit
Outcome results
None listed