Effects of remote ischemic preconditioning in cardiac surgery on incidence and severity of acute kidney injury

Effects of remote ischemic preconditioning in cardiac surgery on incidence and severity of acute kidney injury - RenalRIP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00005333

Enrollment

240

Registered

2013-11-05

Start date

2013-10-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OPS-2013: 5-35, 5-361 (bypass surgery, cardiac valve and septum surgery) N17

Interventions

Group 1: Ischemic preconditioning: Three cycles of upper limb ischemia (5-min blood-pressure cuff inflation to a pressure that is 50 mm Hg higher than the systolic arterial pressure and 5-min cuff def

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Cardiac Surgery with the use of cardiopulmonary bypass 2. Clevelandscore of 6 or more 3. Informed consent

Exclusion criteria

Exclusion criteria: 1. pre-existing AKI 2. kidney transplantation 3. chronic kidney disease with a GFR < 30 ml/min 4. myocardial infarction within the past 7 days 5. peripheral vascular disease affecting the upper limbs 6. hepatorenal syndrome 7. pregnancy 8. drug therapy with sulfonamide and nicorandil

Design outcomes

Primary

Measure	Time frame
Incidence of acute renal failure	—

Secondary

Measure	Time frame
- Severity of acute kidney injury (AKIN criteria) - Duration of renal replacement therapy - Recovery of renal function (Incidence of RRT (renal replacement therapies) on hospital discharge and 3 months after surgery) - Length of ICU stay - Length of hospitalization - Laboratory parameter (creatinine on hospital discharge)	—

Countries

Germany

Contacts

Public ContactCarola Wempe

Universitätsklinikum Münster Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

wempe-c@anit.uni-muenster.de02518347267

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 4, 2026