F95.2 F42
Conditions
Interventions
Group 1: Tourette patients treated with thalamic DBS are examined preoperative as well as 6 and 12 month after operation in regard to psychopathological, neuropsychological, electrophysiological aspek
Sponsors
Universitätsklinikum Köln
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: For OCD and Tourette patients: - chronic course - serious expression with subjective distress and significant impairment of psychosocial functioning levels - The patient agrees after detailed education about DBS and gives his written informed consent - The patient agrees to a detailed evaluation For OCD patients: - OCD (ICD-10: F42) is the main psychiatric diagnosis - strong symptom severity as measured by the YBOCS score - At least one documented fully implemented cognitive-behavioral psychotherapy without sufficient success - at least two unsuccessful drug therapies with SSRIs or clomipramine for 10 weeks in adequate doses - At least one unsuccessful drug augmentation carried out for 10 weeks with one of the following medications: lithium, buspirone or neuroleptics For Tourette patients: - Tourette Syndrome (ICD-10: F95.2) is the main psychiatric diagnosis - strong symptom severity as measured by the score YGTSS - Inadequate symptom relief through drug treatment strategies, as a minimum pre-treatment with preparations from all three pharmacological groups listed (neuroleptics, benzodiazepines, alpha-agonists). This should be documented with adequate doses of at least 3-month treatment periods.
Exclusion criteria
Exclusion criteria: - Acute suicidality - Simultaneously or previously existing schizophrenia according to DSM-IV criteria - Abuse of or dependence on drugs or alcohol in the last six months - Craniocerebral trauma in the anamnesis - Clinically relevant internal or neurological diseases - Pregnancy or breastfeeding - Participation in a clinical trial within the last 30 days before the start of the study - Intellectual deficit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Obsessive compulsive symptoms should be measured 12 month after Operation using the YBOCS (Yale-Brown Obsessive Compulsive Scale). Changes in Tic symptoms in Tourette patients should be measured 12 month after operation using the YGTSS (Yale Global Tic Severerity Scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychopathology: STAI, HZI, IKP, SKID, GAF, DAPP-BQ, BDI, GAF, SCL-90 Neuropsychology: ToL, CPT, FWIT, Stroop-Test, Go/NoGo-Test, Inhibiton of Return, PPI All examinations are executed preoperative as well as 6 and 12 month after operation | — |
Countries
Germany
Contacts
Public ContactDaniel Huys
Uniklinik KölnKlinik für Psychiatrie und Psychotherapie
Outcome results
None listed