Systemic versus local inflammation: Analysis of tonsillar T-cell function as a surrogate marker of the immune status in sepsis versus chronic tonsillitis

Systemic versus local inflammation: Analysis of tonsillar T-cell function as a surrogate marker of the immune status in sepsis versus chronic tonsillitis - HTTS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005313

Enrollment

Registered

2013-11-21

Start date

2013-09-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9 J35.0 J35.1

Interventions

Group 1: Patient with sepsis, tissue sampling of palatine tonsils Group 2: Patients with chronic tonsillitis, tissue sampling of palatine tonsils Group 3: Patients with tonsil hyperplasia, tissue samp

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Group 1 (sepsis patients): adult patients who are asked two weeks after the diagnosis of severe sepsis and / or septic shock and written consent to provide a piece of their tonsils Group 2 (chronic tonsillitis): adult patients with 3 or more episodes of recurrent acute tonsillitis per year that are scheduled for routine tonsillectomy Group 3 (tonsil hyperplasia): adult patients without acute or chronic tonsillitis in history that are scheduled for routine tonsillectomy due to rhonchopathy or obstructive sleep apnea syndrome

Exclusion criteria

Exclusion criteria: Group 1 (sepsis patients): neuromuscular diseases, alcohol abuse, steroid therapy for asthma, COPD and patients likely to die within less than 24 hours, patients after tonsillectomy Group 2 and 3 (chronic tonsillitis and tonsil hyperplasia): sepsis, immunodeficiency, severe chronic diseases in the medical history

Design outcomes

Primary

Measure	Time frame
Difference in the T cell response of patients with sepsis, chronic tonsillitis and tonsil hyperplasia regarding activation, proliferation and apoptosis and thereby investigate the existence of T cell specific parameters to systemic and local inflammation	—

Secondary

Measure	Time frame
Investigation of the use of the tonsils, as the only available secondary lymphoid organ, for the determination of the immune status of patients with sepsis	—

Countries

Germany

Contacts

Public ContactOrlando Guntinas-Lichius

Integriertes Forschungs- und BehandlungszentrumSepsis und SepsisfolgenKlinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde

orlando.guntinas@med.uni-jena.de03641-9-35127

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026