HLA-DR expression and phagocytic activity of monocytes, their subpopulations, of granulocytes and lymphocytes in the course after stem cell and bone marrow transplantation. HLA-DR expression and phagocytic activity of monocytes, their subpopulations, of granulocytes and lymphocytes before and during post-transplant complications such as GvHD, VOD, bacterial and viral infections in the course after stem cell and bone marrow transplantation.
Conditions
Interventions
Group 1: In this study, the analysis is carried out of HLA-DR expression and phagocytic activity of monocytes, their subpopulations, of granulocytes and lymphocytes at 30 pediatric patients and young
Sponsors
Forschungsprogramm der Tübinger Medizinischen Fakultät - ƒortüne-Programm
Eligibility
Sex/Gender
All
Age
6 Months to 40 Years
Inclusion criteria
Inclusion criteria: Pediatric patients and young adults following allogeneic and autologous stem cell transplantation.
Exclusion criteria
Exclusion criteria: Adults over 40 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this prospective study, the analysis is carried out of HLA-DR expression and phagocytic activity of monocytes, their subpopulationen, of granulocytes and lymphocytes per FACS-analysis up to one year after stem cell transplantation at pediatric patients and young adults. Primary endpoint is the time point 365 days after stem cell transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint is the death of included pediatric patients and young adults during the observation period of one year after stem cell transplantation. | — |
Countries
Germany
Contacts
Public ContactMaria Lammerding-Köppel
Dekanat der Medizinischen Fakultät, Bereich Forschung
Outcome results
None listed